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Investigators and Collaborating Scientists of The Crohn's Disease Initiative
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The Crohn's Disease Initiative greatly appreciates the time, effort and expertise of the Investigators and Colaborating Scientists of The Crohn's Disease Initiative.
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Rod Chiodini, Ph.D.
Department of Internal Medicine
Texas Tech University Health Sciences Center
4800 Alberta Avenue
El Paso, TX 79905 US
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Research Statement:
After being away from the field for almost 15-years and watching the field lose focus and objectivity, I want to finish what I started 25-years ago and end this lingering controversy. By employing a focused and objective step-by-step series of investigations, I hope to determine if the association of M. paratuberculosis and Crohn's disease is more than simply a mere association and whether or not M. paratuberculsois is the cause of some cases of Crohn's disease.
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| Chiodini RJ. Hermon-Taylor JT.. The thermal resistance of Mycobacterium paratuberculosis in raw milk under conditions simulating pasteurization. J. Vet. Diagn. Invest. 5:629-631; 1993 | View PDF | | Chiodini RJ, Kreeger JM, Thayer WR.. Use of Rifabutin in Treatment of Systemic Mycobacterium paratuberculosis Infection in Mice Antimicrob. Agents Chemother. 37:1645-1648; 1993 | View PDF | | Chiodini RJ. Crohn's Disease and the Mycobacterioses: a Review and Comparison of Two Disease Entities. Clin. Microbiol. Reviews 2:90-117; 1989 | View PDF | | Chiodini RJ, Van Kruiningen HJ, Thayer WR, Coutu JA.. Spheroplastic Phase of Mycobacteria Isolated from Patients with Crohn's Disease. J. Clin. Microbiol. 24:357-363; 1986 | View PDF | | Chiodini RJ, Van Kruiningen HJ, Merkal RS, Thayer WT, Coutu JA.. Characteristics of an Unclassified Mycobacterium Species Isolated from Patients with Crohn's Disease J. Clin. Microbiol. 20:966-971; 1984 | View PDF |
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William Chamberlin, MD
Medicine
Texas Tech University
4800 Alberta Avenue
El Paso, TX 79905 US
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Research Statement:
As a clinical gastroenterologist, in addition to the general support of the project, I am specifically responsible for all clinical aspects of the program including, but not limited to, recruiting other clinical gastroenterologists, obtaining tissue and biopsy materials, recruiting and obtaining patient consent, patient monitoring, and setting up and monitoring clinical trials.
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| Chamberlin W. Networks, Emergence, Iteration and Evolution ECO 11:91-98; 2009 | View PDF | | Chamberlin W, Naser S. Blood Cultures of 19 Crohn’s Disease Patients. Am J Gastroenterol. 103:802-803; 2008 | View PDF | | Chamberlin W. Importance of the Australian Crohn’s Disease Antibiotic Study. Gastroenterol. 133:1744-1745; 2007 | View PDF | | Chamberlin W, Borody T, Naser S.. MAP-associated Crohn’s Disease: MAP, Koch’s postulates, causality and Crohn’s Disease. Dig Liver Dis 39:792-794; 2007 | View PDF | | Chamberlin W, Ghobrial G, Chehtane M, Naser SA. Successful Treatment of a Crohn’s Disease Patient Infected with Bacteremic Mycobacterium Paratuberculosis. Am J Gastroenterol. 102:689-691; 2007 | View PDF | | Chamberlin WM, Naser SA.. Integrating theories of the etiology of Crohn’s Disease. On the etiology of Crohn’s Disease: Questioning the Hypotheses. Med Sci Monit. 12:27-33; 2006 | View PDF | | W. Chamberlin, D.Y. Graham, K. Hulten ,H.M.T. El-Zimaity, M.R. Schwartz, S. Naser, I. Shafran, F.A.K. El-Zaatari. Review article: Mycobacterium avium subsp. paratuberculosis as one cause of Crohn's disease. Aliment. Pharmacol. Ther. 15:337-346; 2001 | View PDF |
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Manuel Llano, M.D.,Ph.D.
Biological Sciences
University of Texas at El Paso
500 W. University
El Paso, TX 79968 US
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Research Statement:
As a molecular biologist with a personal interest in Crohn's Disease, I will provide my years of experience in quantitative real-time PCR and other molecular biologic techniques to the project.
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| Marshall HM, Ronen K, Berry C, Llano M, Sutherland H, et al. Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting. PLoS ONE 2:e1340-1371; 2007 | View PDF | | Ciuffi A., Llano M., Poeschla E.M., Marshall H., Hoffman C., Shinn P., Hannenhalli S., Ecker J., Bushman F.. A role for LEDGF/p75 in targeting HIV DNA integration. Nat. Med. 11:1287-1289; 2005 | View PDF | | Vanegas M., Llano M., Delgado S., Thompson D., Peretz M., Poeschla E.M. Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. J. Cell. Sci. 118:1733-1743; 2005 | View PDF | | Llano M., Vanegas M., Fregoso O., Saenz D., Chung S., Peretz M., Poeschla E.M. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a com J. Virol. 78:9524-9537; 2004 | View PDF | | Llano M., Delgado S., Vanegas M., Poeschla E.M. LEDGF/p75 prevents proteasomal degradation of HIV-1 integrase. J. Biol. Chem. 279:55570-55577; 2004 | View PDF | | Garcia P., De Heredia A.B., Bellon T., Carpio E., Llano M., Caparros E., Aparicio P., Lopez-Botet M.. Signaling via CD70, a member of the TNF family regulates T cell functions. J. Leukoc. Biol. 76:263-270; 2004 | View PDF |
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Meet the Scientists
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